Dexamethasone-Loaded PLGA Microspheres: Effective and Sustained Anticancer Drug Delivery System

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Abstract
Pharmacology, Toxicology and Biomedical Reports,2017,3,3,55-61.
Published:January 2018
Type:Original Article

Dexamethasone-Loaded PLGA Microspheres: Effective and Sustained Anticancer Drug Delivery System

Elangovan Vimalkumar1, Chinnaperumal Kamaraj2*, Pachiyappan Rajiv Gandhi

1Research Scholar, Department of Zoology, Auxilium College (Autonomous), (Affiliated to Thiruvalluvar University), Gandhi Nagar, Vellore, Tamil Nadu, INDIA.

2Department of Marine Biotechnology, Periyar University, Salem, Tamil Nadu, INDIA.

Abstract:

Objective: Encapsulation of dexamethasone (DEX) anticancer drug with Poly (d, l-lactide-co-glycolide) (PLGA) microsphere (MS) was carried out for sustained release system. Methods: The characterizations of MS were analyzed using XRD, FTIR, RP-HPLC, TEM, CLSM, and XRD patterns and reported the physical state of the encapsulated PLGA microsphere (DEXPLGA MS). Results: The presence of 2 θ peaks values at 33.17°, 35.63°, 49.46° and 54.09° confirmed the semi-crystalline phase for the DEX drug. FTIR showed peaks at 1695 cm−1, 1644 cm−1 and 1602 cm−1 were shown to be confirming DEX encapsulation. The MTT assay showed a greater cellular uptake of DEX-PLGA MS and the new formulation showed steady and sustained release of DEX resulting in a lower short term cytotoxic effect against HEP-G2 cells. Conclusion: In the present study, the drug encapsulation microsphere is non-toxic, simple, and an ideal method for anticancer drug release. The present results revealed that the use of DEX-PLGA MS offers large-scale production of biocompatible microspheres that can be used against HEP-G2 cells.