Objective: Therefore this study was aimed to determine the prevalence of Hepatitis B and C infections among the multi-transfused Thalassaemic patients. Methodology: The medical records of total 100 patients with thalassaemia attending the Day Care Ambulatory Unit for blood transfusion in Raja Permaisuri Bainun Hospital was collected in order to extract relevant information pertaining to the study. Results: Among the 100 multi-transfused thalassaemic patients, 48% were females and 52% were males. 24% was infected with viral hepatitis, among them 18% by Hepatitis C, 4% by Hepatitis B, and only 2% were infected by both Hepatitis B & C. Difference in occurrence of hepatitis in different gender groups was not significant, on the other hand difference in occurrence of hepatitis in different ethnic groups was highly significant. Discussion and Conclusion: Acquisition of hepatitis C as well as hepatitis B is a serious risk for multi-transfused thalassaemia patients. Blood screening in Malaysia has significantly reduced the risk of hepatitis B and C associated with blood transfusion. However, the risk is still there. So, the health care providers who are involved with the management and providing blood transfusion to the thalassaemic patients should be aware of this problem, and should pay more attention to prevent these known complications.