@article {30, title = {In silico Screening of Thiazolidine 4-one Derivatives for Antitumor Activity}, journal = {Pharmacology, Toxicology and Biomedical Reports}, volume = {3}, year = {2017}, month = { October 2017}, pages = {35-38}, type = {Original Article}, chapter = {35}, abstract = {

Objectives: To evaluate the potent histone deacetylase inhibitory activity of thiazolidine 4-one derivatives using Molegro virtual docker 6.0 version. Methods: Chromone derivatives were drawn using ACD Chem Sketch software, Histone deacetylase a well-known tumor inhibitor is chosen as standard. Insilco docking studies were carried out using Molegro virtual docker version 6.0. Results: Docking results showed all the selected Ligands has binding energy ranging between 40.36 kcal/mol to-47.67kcal/ mol when compared with that of standard which has binding energy 40.42 Conclusion:Thiazolidone derivatives reported best histone deacetylase inhibitory activity because of its structural parameters. Further study on thiazolidine-4-one derivatives and in vivo and in vitro study are necessary to develop target moieties for treatment of tumor.

}, keywords = {Binding affinity, Histone deacetylase, Molegro virtual docker, Thiazolidine 4-one, Thiazolidone.}, doi = {10.5530/PTB.2017.3.6}, url = {http://fulltxt.org/article/350}, author = {Palayyan Muralidharan and Gejalakshmi Subramaniam} }