@article {68, title = {Menstrual Discomforts and the Treatment Preferred by University Students}, journal = {Pharmacology, Toxicology and Biomedical Reports}, volume = {1}, year = {2015}, month = {24 June 2015}, pages = {111-120}, type = {Original Article}, chapter = {3}, abstract = {

Menstrual disorders are one of the major problems faced by women all around the world may have considerable psychological and physical consequences in student community and contribute to absenteeism. Objective: This study was conducted to investigate student{\textquoteright}s experience of and their response to menstrual symptoms and also to understand the impact of the respondents{\textquoteright} study background on the treatment preferred for the menstrual symptoms. Methods: The survey was carried out using a pre-validated questionnaire consisting 29 questions, organized into two sections viz., the first section includes 10 items on the demographic details; second section includes 19 questions related menstrual cycle and the treatment preferred. Results: A total of 592 questionnaires were returned by the participants giving a response rate of 70\% and only 569 questionnaires were completely filled. Among the participants, 34.97\% of students responded to have irregular menstrual cycle. The participants responded that menstrual discomforts was a reason for them to avoid physical exercise (64.0\%), feel depressed (54.8\%), absent from classes (20.0\%)and also that it affectedwork ability (44.1\%), academic activities (32.3\%), social relationship (30.2\%). Conclusion: In this study, the most common discomfort experienced by these students was pain crampsleading to usage of pain killers as their main choice. Among alternative medicines, Chinese medicine was their most preferred choice of treatment, whereas in home remedies, raw ginger was their choice. Aneducational intervention regarding menstrual problems and the importance to seek medical advice can help these students to be concerned on their health.

}, keywords = {Alternative medicines, Home remedies, Menstrual discomforts, Preferred, Students, Treatment.}, doi = {10.5530/PTB.1.3.4}, author = {Sivadasan Shalini and SundarHemalatha and Wong Chui Ting and ManiamYoshita and BalasubramanianGanesh Pandian and Abdul Nazer Ali and Kasi Marimuthu and Veerasamy Ravichandran} } @article {74, title = {QSAR Study on Arylthioquinoline Derivatives as Anti-tubercular Agents}, journal = {Pharmacology, Toxicology and Biomedical Reports}, volume = {1}, year = {2015}, month = {6th May, 2015}, pages = {81-86}, type = {Original Article}, chapter = {81}, abstract = {

Aim: The major issue for many anti-tubercular agents is the resistance of Mycobacterium tuberculosis strains. Quinoline compounds serve as anti-mycobacterial agents with encouraging anti-tubercular activity. The main aim of this study is to develop 2D QSAR models for a series of arylthioquinoline to predict their ideal characteristics as potential anti-tubercular agents. Materials and Methods: Used CS Chem Office 2004 and Molecular Modeling Pro 6.1.0 software for modeling and models development. Some of the statistical parameters were calculated by using QSARINS (HYPERLINK "http:// www.qsar.it/"www.qsar.it). We have used MLR techniques to develop QSAR models. The developed QSAR models were found to be statistically significant based on internal and external validation parameters. Results: The significance and predictive ability of the developed QSAR model was confirmed as it satisfied the following conditions: r2=0.817\>0.6; CCCtr=0.899\>0.85; q2LOO=0.729\>0.5; pred_r2=0.922\>0.6; pred_r2se=0.186; CCCpred=0.907\>0.85; r2m=0.753\>0.5; r{\textquoteright}2m=0.714\>0.5; Δ r2m=0.039\<0.2k{\textquoteright}=0.966; k=1.014 (0.850.5; q2LMO=0.650\>0.5. The major outcome of this study is that the density of the molecules significantly influences the anti-tubercular activity of novel arylthioquinoline derivatives. Conclusion: It can be concluded that the proposed models explained the relationship of the density of arylthioquinolines with their anti-tubercular activity and these can be used as guidance for synthesis of new anti-tubercular agents.

}, keywords = {3-heteroarylthioquinolinederivatives, Anti-tubercular agents, Quantitative structure activity relationship, Tuberculosis.}, doi = {10.5530/PTB.1.2.8}, author = {Veerasamy Ravichandran and Sivadasan Shalini and Krishnamoorthi Venaktes Kumar and Rajak Harish and Krishnan Suresh Kumar} }