02719nas a2200265 4500008004100000245013000041210006900171260001300240300001000253490000600263520182200269653003602091653001602127653003002143653003002173653003802203100002002241700001902261700001902280700002602299700001702325700002702342700002502369856005902394 2016 eng d00aAntihypergluco-lipidemic and Antioxidant activities in Aqueous methanol Extract of Some Vegetables Peel: An in vitro Analysis0 aAntihyperglucolipidemic and Antioxidant activities in Aqueous me cDec 2015 a15-200 v23 a

Objective: To examine phytochemical constituents, antihyperglycemic, antihyperlipidemic and free radical scavenging activities in 50% methanol extract of peels of Cucumis melo var. chito (CM), Cucumis pubescens (CP), Lagenaria siceraria (LS), Luffa acutangula (LA), and Momordica charantia (MC) applying in vitro methods. Material and Methods: Total polyphenol (gallic acid equivalent; GAE), flavonoid (rutin equivalent; RE) and anthocyanin (cyanidine-3-glucoside equivalent; CGE) content were estimated. The 2,2-diphenyl-1-picrylhydrazyl (DPPH); 2,2-azinobis(3-ethylbenzthiazoline- 6-sulphonic acid) (ABTS.+); nitric oxide (NO) scavenging; nitro blue tetrazolium (NBT) reduction; advanced glycation end-products (AGEs), intestinal α-glucosidase, pancreatic lipase and liver Protein-tyrosine phosphatase 1β (PTP 1β) inhibitory activities were examined in vitro. Results: Peel of CM (1190 μgGAE/g) and MC (923 μgGAE/g) was rich in polyphenol and flavonoids (68.8, 145.1 μgRE/g respectively). Anthocyanin content was more in MC (167 mg CGE/100 g) than others. LS potently scavenged ABTS.+ (SC50, 99 μg) and DPPH (SC50 , 0.6 mg) radicals. Inhibition of vesperlysinelike AGEs (71.5%) was significant (p<0.006) than pentosidine-like AGEs (14.8%) by LA peel. Inhibition of pentosidine-like AGEs was significant (p<0.009) by CM than CP peel. MC reduced (84.5 %) only vesperlysine-like AGEs. Intestinal α-glucosidase was inhibited (23.02 %) by MC peel only. Pancreatic lipase was inhibited by CM (74.5%) and CP (58.6 %) peels. The LS reduced PTP 1β (32.1 %) more potently than others. Conclusion: Vegetable peels present variable degree of antioxidant, antihyperglycemic and antihyperlipidemic activities.

10aAdvanced glycation end products10aAntioxidant10aIntestinal α-glucosidase10aPorcine pancreatic lipase10aProtein-tyrosine phosphatase 1β.1 aShukla, Srishti1 aAnusha, Ambati1 aArchana, Katta1 aKumar, Dommati, Anand1 aZehra, Amtul1 aReddy, Yellu, Narsimha1 aTiwari, Ashok, Kumar uhttp://ptbreports.org/article/2016/2/1/105530ptb201614