Objective: To examine phytochemical constituents, antihyperglycemic, antihyperlipidemic and free radical scavenging activities in 50% methanol extract of peels of Cucumis melo var. chito (CM), Cucumis pubescens (CP), Lagenaria siceraria (LS), Luffa acutangula (LA), and Momordica charantia (MC) applying in vitro methods. Material and Methods: Total polyphenol (gallic acid equivalent; GAE), flavonoid (rutin equivalent; RE) and anthocyanin (cyanidine-3-glucoside equivalent; CGE) content were estimated. The 2,2-diphenyl-1-picrylhydrazyl (DPPH); 2,2-azinobis(3-ethylbenzthiazoline- 6-sulphonic acid) (ABTS.+); nitric oxide (NO) scavenging; nitro blue tetrazolium (NBT) reduction; advanced glycation end-products (AGEs), intestinal α-glucosidase, pancreatic lipase and liver Protein-tyrosine phosphatase 1β (PTP 1β) inhibitory activities were examined in vitro. Results: Peel of CM (1190 μgGAE/g) and MC (923 μgGAE/g) was rich in polyphenol and flavonoids (68.8, 145.1 μgRE/g respectively). Anthocyanin content was more in MC (167 mg CGE/100 g) than others. LS potently scavenged ABTS.+ (SC50, 99 μg) and DPPH (SC50 , 0.6 mg) radicals. Inhibition of vesperlysinelike AGEs (71.5%) was significant (p<0.006) than pentosidine-like AGEs (14.8%) by LA peel. Inhibition of pentosidine-like AGEs was significant (p<0.009) by CM than CP peel. MC reduced (84.5 %) only vesperlysine-like AGEs. Intestinal α-glucosidase was inhibited (23.02 %) by MC peel only. Pancreatic lipase was inhibited by CM (74.5%) and CP (58.6 %) peels. The LS reduced PTP 1β (32.1 %) more potently than others. Conclusion: Vegetable peels present variable degree of antioxidant, antihyperglycemic and antihyperlipidemic activities.