Objectives: This study aims to identify antibiotic prescribing patterns in Riyadh’s Primary health care centers (PHCs). Methods: The study was a one-month cross-sectional medication prescription survey conducted at 25 PHCs in Riyadh. Results: A total of 18031 prescriptions were recorded in all 25 PHCs during the study period. Antibiotics were present in 3,879 (21.51%) of all prescriptions. The percentage of antibiotics prescribed varied from one primary care center to another; the highest documented percentage was 38.01 %. In comparison, the lowest proportion was discovered to be 10.56% of total antibiotics prescribed, with 3,131 (80.67 %) being bactericidal and 748 (19.3 %) being bacteriostatic. Capsules were the most commonly prescribed antibiotic dosage form 1,240 (32%), Amoxicillin was the antibiotic most frequently prescribed 1628 (42%), followed by a combination of Amoxicillin/Clavulanate 797 (20.5%). Of the total prescriptions, 2931 (75.6%) were written with generic names, while 948 (24.4%) were written with brand (trade) names. Amoxicillin was the most commonly prescribed antibiotic with a generic name (52.7%), while Amoxicillin/Clavulanate was the most usually prescribed antibiotic with the brand name “Augmentin” (69.4%). The frequency of antibiotics prescribed to patients who did not have a documented indication for Amoxicillin was 270. (6.9%). Conclusion: Antibiotics were prescribed in one-third of PHC prescriptions. Antimicrobial stewardship programs and training for healthcare professionals are needed at PHCs in Riyadh, Saudi Arabia.