Objective: In this study, we aimed to illustrate pharmacy infection control wastages and spill cleaning policy as a new initiative in Saudi Arabia. Methods: This narrative review of pharmacy infection control emphasizes wastages and spill cleaning. A literature search was done using various databases containing PubMed, Medline, and Google Scholar. About specific pharmacy practice infection control policies and procedures. The search time was from the 1960s to October 2021. The topic was English, including narrative review, systemic review, meta-analysis, and guidelines across hospitals and community pharmacy services. Moreover, the national and international guidelines of general research in hospital practice. The committee of pharmacy research formulated and consisted of various experts, including clinical pharmacists, drug information pharmacists, and infection control specialists. The first author drafted the policy guidelines, and the second author reviewed and corrected them. The third author, an infection control specialist, revised the final document. The study emphasizes policy and procedures related to wastage and spill cleaning for pharmacy infection control. Results: The wastages and spill cleaning policy of pharmacy infection control consisted of various items, including the types of pharmacy wastages (biohazard wastages, non-biohazard wastages, sharp material), steps in the management of pharmacy wastages, spill kit contents, and cleaning of spill material. Conclusion: The policy and procedures of wastages and spill cleaning are new initiative procedures aimed at pharmacy infection control. In pharmacy settings, it is part of the biohazard and safety foundation. As such, waste management and spill clean-up policies are critical in pharmaceutical care services to improve safe disposal.