@article {57, title = {Aphrodisiac Activity of Cocos Nucifera Attentuates Cerric Sulphate Induced Infertility in Male Rats}, journal = {Pharmacology, Toxicology and Biomedical Reports}, volume = {1}, year = {2015}, month = {5th May, 2015}, pages = {62-68}, type = {Original Article}, chapter = {62}, abstract = {

Objective: In the present study, we examined the effect of hydroalcoholic extract of apical bud of cocos nucifera (HACN) in ceric sulphate induced infertility in male rats. Methods: Rats weighing 180 to 200 gm were randomized into 4 groups of 6 animals each that included saline treated rats (normal) were orally administered once daily with 0.5ml of distilled water, Ceric sulphate treated (1 mm/100 gm., s.c.) and HACN treated (200 and 400 mg/kg., p.o.). Ceric sulphate was given to the rats for 7 days for all the groups except saline treated rats then followed by administration of the HACN extract for 21 days. Parameters Evaluated: Sexual behavioural parameters including mount and intromission frequency (MF and IF) and mount, intromission and ejaculation latency (ML, IL, EL) as well as post ejaculatory interval (PEI) and body weight (BW) were recorded in male rats one hour after injection of extract by mating with a receptive female (1:1). Biochemical evaluation such as serum and cauda epididymidal testosterone and dihydrotestosterone (DHT) and histopathological analysis of testis were also assessed. Results: Ceric sulphate treated rats significantly decreased sexual behaviour and also reduced the serum and cauda epidymidal tissue testosterone and DHT when compared to control rats. All these changes were significantly attenuated by ceric sulphate rats (with HACN extract). Ceric sulphate was found to be inducing sterility in male rats which has been confirmed after analyzing all the parameters of the study. Conclusion: From the results it may be concluded that hydroalcoholic extract of cocos nucifera may be used as a good aphrodisiac activity which can promote the fertility rate.

}, keywords = {Aphrodisiac, ceric sulphate, cocos nucifera, infertility, Testosterone}, doi = {10.5530/PTB.1.2.5}, author = {Ramakrishnan Prakash and Rajulu Dheeraj and Palayan Muralidharan and Krishnan Karthickeyan and Raji Vijayakumar and Thiraviam Purushoth Prabu} } @article {62, title = {Gastroprotective and antisecretory properties of methanolic extract of Trianthema portulacastrum. L in aspirin \& pyloric ligature induced gastric ulcer in rats}, journal = {Pharmacology, Toxicology and Biomedical Reports}, volume = {1}, year = {2015}, month = {16th May 2015}, pages = {87-91}, type = {Original Article}, chapter = {87}, abstract = {

Objective: The present study was carried out to investigate antiulcer activity of methanolic extract of whole plant of Trianthema portulacastrum L. belonging to the family of Aizoaceae in pylorus ligated and aspirin induced gastric ulcer in rats. Methods: Preliminary methanol extract of Trianthema portulacastrum L. (METP) was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Based on which, two dose levels i.e. 250 and 500 mg/kg were selected for the further study. In both models, we assessed ulcer index, gastric juice volume, gastric pH and total acidity. Ranitidine (50 mg/kg) was used as the positive control. Results: In present study, METP showed significantly decrease in ulcer index in both ulcer models in a dose dependent manner. METP showed a dose dependent significant decrease in gastric juice and total acidity in both the models. A dose dependent increase in gastric pH and total adherent gastric mucus was also produced in METP treated groups. Conclusion: The present study suggested that the antiulcer activity of METP on pylorus ligation induced gastric ulcer can due to anti secretory activity. The mechanism of protection against aspirin induced gastric ulcer can be attributed to 5- lipoxygenase pathway.

}, keywords = {Aspirin, Gastric ulcer, Pylorus ligated, Trianthema portulacastrum, ulcer index.}, doi = {10.5530/PTB.1.2.9}, author = {Ramakrishnan Prakash} }