01623nas a2200205 4500008004100000245008100041210006900122260001800191300001000209490000600219520098800225653002101213653002401234653002701258653002301285653001801308100002701326700002901353856003501382 2017 eng d00aIn silico Screening of Thiazolidine 4-one Derivatives for Antitumor Activity0 aIn silico Screening of Thiazolidine 4one Derivatives for Antitum c October 2017 a35-380 v33 a

Objectives: To evaluate the potent histone deacetylase inhibitory activity of thiazolidine 4-one derivatives using Molegro virtual docker 6.0 version. Methods: Chromone derivatives were drawn using ACD Chem Sketch software, Histone deacetylase a well-known tumor inhibitor is chosen as standard. Insilco docking studies were carried out using Molegro virtual docker version 6.0. Results: Docking results showed all the selected Ligands has binding energy ranging between 40.36 kcal/mol to-47.67kcal/ mol when compared with that of standard which has binding energy 40.42 Conclusion:Thiazolidone derivatives reported best histone deacetylase inhibitory activity because of its structural parameters. Further study on thiazolidine-4-one derivatives and in vivo and in vitro study are necessary to develop target moieties for treatment of tumor.

10aBinding affinity10aHistone deacetylase10aMolegro virtual docker10aThiazolidine 4-one10aThiazolidone.1 aMuralidharan, Palayyan1 aSubramaniam, Gejalakshmi uhttp://fulltxt.org/article/350