02402nas a2200241 4500008004100000245012000041210006900161260001900230300001000249490000600259520162000265653002501885653002201910653002301932653001901955653002301974100002901997700002802026700001702054700002602071700001702097856004602114 2017 eng d00aPhysical Endurance Enhancement of Withania somnifera Milk Treated Powder Compared to Commercial Preparation in Mice0 aPhysical Endurance Enhancement of Withania somnifera Milk Treate cSeptember 2017 a70-730 v33 a

Background: The duration one can apply energy to an activity is limited by stamina (endurance). Recent studies using extracts of ashwagandha (Withania) root powder, either aqueous or ethanolic suspension, have demonstrated a significant increase in physical endurance. Milk treatment enhances the potency of herbal preparations. Objectives: To evaluate the efficacy of milk treated root powder of ashwagandha as compared to standard preparation, in enhancing the physical endurance in mice, using swim endurance model. Methods: Male, Swiss albino mice (31 – 35 g, 6 – 8 weeks old) were randomized into 3 groups of 6 animals each : Control - Carboxy Methyl Cellulose 0.5%, Standard - commercial preparation of ashwagandha (100mg / Kg), test - milk treated ashwagandha root powder (100 mg/ Kg). Study drugs were administered per oral, once daily, for 7 days. On day 8, animals were allowed to swim in a propylene tank of dimension 40 cm x 25 cm x 15 cm, with water level at 25 cm. The animals were allowed to swim till exhaustion. The end point of swim endurance was when the mice near drowned. Results: There was a significant increase in the physical endurance in the treatment as compared to control .One way ANOVA (F (2, 15) = 13.000, p = 0.001), Tukey’s post hoc test of milk treated vs standard (p = 0.207) however, was not significant. Conclusion: Milk treated Withania somnifera was not significantly different as compared to the standard preparation, though it was better than the control.

10aAntifatigue activity10aGlycowithanolides10aPhysical endurance10aSwim endurance10aWithania somnifera1 aMuralidharan, Pradhyumna1 aD’Cruz, John, Michael1 aToms, Tomson1 aRaj, Jeffrey, Pradeep1 aRao, Mangala uhttps://ptbreports.org/article/2017/3/3-2