01933nas a2200217 4500008004100000245012100041210006900162260001600231300001000247490000600257520124400263653001401507653002601521653001301547653002101560653001501581100002301596700002901619700002101648856004601669 2016 eng d00aSynthesis and characterization of PEGylated guar gum based nanoparticles: New approach in novel drug delivery system0 aSynthesis and characterization of PEGylated guar gum based nanop cAugust 2016 a61-650 v23 a

Objective: To investigate the synthesis of guar gum PEGylation and the nanoparticles preparation and evaluation of drug release characters were studied. Methods: The PEGylated particle was prepared by emulsification with cold homogenization. Results: The Acyclovir loaded nanoparticles were uniform and spherical with smooth surface. The entrapment efficiency (EE %) was in range of 60-95%. The entrapment was increased with increase in concentration of PEGylated guar gum. The particle size of Acyclovir nanoparticle was in range between 234.8-879.6 nm with polydespersibility range of 0.006-0.024, which reveals monodisperse nature. The PEGylated nanoparticle showed sustained drug release at 24 hours in the range of 54.28-62.58%. The drug release behaviour was reported by zero order release with diffusion and erosion mechanism. Conclusion: The PEGylation was done successfully with guar gum. These PEGylated guar gum was produced spherical shaped nanoparticles and it was circulating and sustained the drug release in biocompatible manner. Acyclovir PEGylated nanoparticle was best choice for prolonged the drug release in HIV treatment.

10aAcyclovir10aEntrapment Efficiency10aGuar Gum10aIn vitro Release10aPeGlyation1 aVijayan, Venugopal1 aPurushothaman, Munuswamy1 aRaj, James, Anbu uhttps://ptbreports.org/article/2016/2/3-2